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The next category groups together hospitals considered urban or rural, in terms of whether they receive the IME adjustment, the DSH adjustment, both, or neither

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Notably, hypermetabolism and increased FGF-21 are frequently associated with mitochondrial disorders [57, 58] and recent studies have shown that FGF-21 can modulate mitochondrial bioenergetics and dynamics by inhibiting mitochondrial fission and oxidative stress [53, 59]